Acute Phase Inflammatory
Gene co-expression module in Colorectal carcinoma
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes APOL1, SAA1, SAA2 are acute-phase/inflammatory response genes induced by cytokines (IL-6, TNF, IFN). XAF1 and BIRC3 are apoptosis regulators upregulated in inflammatory/interferon contexts. TYMP (thymidine phosphorylase) is an IFN-inducible enzyme. RNF213 is an interferon-stimulated gene with roles in innate immunity. LGALS3BP is an interferon-regulated secreted protein. PI3 (elafin) is an anti-protease induced in mucosal inflammation. DHRS9 is expressed in inflammatory/differentiation contexts. This module captures an acute-phase and interferon-associated inflammatory response, distinct from M38's NF-κB chemokine program but complementary — both reflect tumor-associated inflammation. The SAA1/SAA2 acute-phase component distinguishes this module.
Genes
Most correlated modules
- Growth Arrest Senescence · correlation 0.74
- ECM Invasion Program · correlation 0.73
- NF-κB Chemokine Response · correlation 0.71
- STAT3 Oncogenic Signaling · correlation 0.70
- Epithelial Cell Adhesion · correlation 0.68
- Type I Interferon · correlation 0.65
- IFN-γ Antigen Presentation · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.