IFN-γ Antigen Presentation
Gene co-expression module in Colorectal carcinoma
| Category | Immune evasion |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 15 of 15 genes have a known function matching the annotation |
Why this annotation
The module is defined by MHC class I (HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, B2M) and class II (HLA-DRA, HLA-DPA1, HLA-DRB1, CD74) molecules, antigen processing machinery (PSMB8/β5i, PSMB9/β1i — immunoproteasome subunits; TAP1 — peptide transporter; PSME1/PSME2 — proteasome activators), all strongly induced by IFN-γ. This is a classic interferon-γ-driven antigen presentation module. Neighbor M1 captures Type I IFN response; M80 captures IFN-γ-driven MHC/antigen presentation, consistent with the same interferon neighborhood. These two modules together reflect the IFN response landscape in CRC, with M80 specifically representing antigen presentation upregulation relevant to immune evasion or immune recognition.
Genes
Most correlated modules
- Type I Interferon · correlation 0.67
- Acute Phase Inflammatory · correlation 0.64
- NF-κB Chemokine Response · correlation 0.56
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.