Protein Homeostasis
Gene co-expression module in Colorectal carcinoma
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes span translation initiation (EIF6, EIF2S2), proteasomal degradation (ADRM1/Rpn13, PSMA7), RNA-binding/processing (RALY), protein chaperoning (PFDN4/prefoldin), endosomal sorting (CHMP4B/ESCRT-III), and ER-Golgi trafficking (ERGIC3). All genes show uniform expression across cell subsets with ~70% detection, consistent with constitutively active housekeeping programs. The module reflects broad proteostasis maintenance rather than any specialized or disease-specific program. TNNC2 and PRR13 are peripheral/weak members that dilute coherence slightly but do not redirect the overall identity.
Genes
Most correlated modules
- ER Protein Processing · correlation 0.80
- Translation Initiation Factors · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.