ER Protein Processing
Gene co-expression module in Colorectal carcinoma
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 8 genes have a known function matching the annotation |
Why this annotation
SERINC3 (serine incorporator, membrane lipid/sphingolipid metabolism), YWHAB (14-3-3 beta, signaling scaffold), RPN2 (dolichyl-diphosphooligosaccharide protein glycosyltransferase, N-glycosylation/ER), HM13 (signal peptide peptidase, ER membrane), DDX27 (nucleolar RNA helicase, ribosome biogenesis), CPNE1 (copine, membrane binding), TOP1 (topoisomerase I), NUDT4 (nudix hydrolase). The module is mixed but several genes point to ER membrane protein processing (RPN2, HM13, SERINC3) alongside general housekeeping functions. Given the neighborhood of RNA/chromatin modules, this likely represents a housekeeping ER/membrane protein processing program.
Genes
Most correlated modules
- Protein Homeostasis · correlation 0.80
- Chromatin-coupled Splicing · correlation 0.78
- Post-transcriptional Regulation · correlation 0.76
- WNT Stem Cell · correlation 0.76
- Lysosomal Autophagy Membrane · correlation 0.74
- Ceramide Lipid Metabolism · correlation 0.72
- RNA Splicing · correlation 0.70
- Ribosome Biogenesis · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.