Translation Initiation Factors
Gene co-expression module in Colorectal carcinoma
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
EIF3E and EIF3H are subunits of the eukaryotic initiation factor 3 (eIF3) complex, which overlaps with neighbor M67's EIF3 core. POLR2I is an RNA Polymerase II subunit, UXT is a transcriptional cofactor, PABPC1 is poly-A binding protein involved in translation, and IGBP1 stabilizes PP2A involved in translation regulation. NDUFB11 and NDUFA11 add Complex I signal consistent with the mitochondrial neighborhood. The dominant program is translation initiation and transcription co-factors.
Genes
Most correlated modules
- Mitochondrial Import & Complex I · correlation 0.93
- SUMOylation Pathway · correlation 0.89
- Transcriptional Ubiquitin Regulation · correlation 0.85
- eIF3 Translation Initiation · correlation 0.82
- OxPhos Complex III/IV · correlation 0.81
- Protein Homeostasis · correlation 0.79
- RNA Pol I/III Transcription · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.