G2/M Checkpoint
Gene co-expression module in Dendritic cells
| Category | Proliferation |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 16 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes are classic G2/M transition and mitotic checkpoint markers: UBE2C (APC/C E2, mitotic exit, 219x in prolif_DC), CCNB1 (cyclin B1, G2/M), TOP2A (topoisomerase IIa, chromosome segregation, 71x), CENPF (kinetochore, 43x), AURKA (Aurora kinase A, mitotic entry/spindle, 11x), NCAPD2 (condensin I), BUB3 (spindle checkpoint), PTTG1 (securin, sister chromatid separation), SKA2 (kinetochore-microtubule attachment), CKAP2 (cytoskeleton-associated, mitosis), KIF20B (kinesin, cytokinesis), KPNA2 (importin alpha, mitotic regulation), HMGB3 (chromatin), ANP32E (chromatin remodeling). This is a G2/M checkpoint and chromosome segregation module, distinct from M50 (spindle assembly) and M97 (S-phase replication). Together these three modules dissect the full cell cycle of prolif_DCs.
Genes
Most correlated modules
- Mitotic Spindle · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.