Mitotic Spindle
Gene co-expression module in Dendritic cells
| Category | Proliferation |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 18 of 19 genes have a known function matching the annotation |
Why this annotation
Hub genes are quintessential mitotic markers: CDK1 (master mitotic kinase, 161x in prolif_DC), MKI67 (Ki-67, mitosis marker, 103x), MAD2L1 (spindle assembly checkpoint, 42x), NUSAP1 (spindle organization, 30x), STMN1 (microtubule destabilizer, 33x), KIFC1 (kinesin motor, mitosis), SMC2/SMC4 (condensin complex), TUBA1B/TUBB4B (tubulin), HMGB2/HMGN2 (chromatin remodeling during mitosis), CKS1B (CDK regulatory subunit), TMPO (nuclear lamina, mitosis), CENPW/CENPN (centromere proteins), UBE2S (APC/C ubiquitin ligase, mitotic exit), MZT1 (gamma-TuRC, spindle pole). This is a coherent mitotic spindle/M-phase module, distinct from the S-phase module M97.
Genes
Most correlated modules
- G2/M Checkpoint · correlation 0.94
- S-phase Replication · correlation 0.85
- Replication Licensing · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.