Monocyte-derived cDC2
Gene co-expression module in Dendritic cells
| Category | Pathogen response |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes include FCN1 (ficolin-1, pattern recognition receptor highly expressed on monocyte-derived cDC2s), CD300E (activating innate immune receptor on monocytes/cDC2s), LILRA2 (inhibitory Ig-like receptor), S100A4 and S100A6 (calcium-binding myeloid proteins), TSPO (mitochondrial translocator protein involved in innate immune sensing), CAPN2 (calpain protease), CSTA (cystatin A, cysteine protease inhibitor), ARHGAP26. Strong cDC2 enrichment throughout. FCN1 and CD300E are hallmark monocyte-derived cDC2 innate immune receptor genes. This module represents monocyte-derived cDC2 innate immune receptor expression, distinct from the differentiation program in M77.
Genes
Most correlated modules
- Innate Myeloid Sensing · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.