Innate Myeloid Sensing
Gene co-expression module in Dendritic cells
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 20 genes have a known function matching the annotation |
Why this annotation
Top hub genes include LILRB2, LILRA5, LILRB4 (inhibitory/activating leukocyte Ig-like receptors), FPR1, FPR3 (formyl peptide receptors for pathogen/damage sensing), FCER1G (Fc receptor gamma chain), ADGRE2, CASP1 (inflammasome effector), IL1RN (IL-1 receptor antagonist), SERPINA1, and TIMP1. This combination is characteristic of cDC2/mDC innate sensing and inflammasome-linked inflammatory activation, with inhibitory receptor co-expression suggesting a regulatory balance. PTAFR (platelet-activating factor receptor) and ETS2 support myeloid inflammatory identity. The module is enriched in cDC2 and mDC subsets. The delta_inflammation trend is positive but not significant, suggesting a baseline myeloid inflammatory program rather than acute inflammation-driven. Neighbor M69 (tolerogenic mDC) and M101 (IFN response) support a broader mDC activation neighborhood.
Genes
Most correlated modules
- JAK-STAT Cytokine Signaling · correlation 0.81
- Tolerogenic DC Signaling · correlation 0.80
- Type I Interferon · correlation 0.78
- IFN-gamma Response · correlation 0.67
- Monocyte-derived cDC2 · correlation 0.66
- MHC-II Presentation · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.