Mitotic Nuclear Envelope
Gene co-expression module in Dendritic cells
| Category | Proliferation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
Small 8-gene module with strong prolif_DC enrichment. LBR (lamin B receptor) is a nuclear envelope protein essential for nuclear reassembly after mitosis and is a canonical proliferation marker. CKAP5 (ch-TOG/XMAP215) is a microtubule polymerase critical for mitotic spindle assembly, enriched in prolif_DC (3.5x). CLEC11A is a hematopoietic growth/survival factor expressed in proliferating progenitors. GAPT (GRB2-associated phosphoprotein) is enriched in prolif_DC (4.2x). SLC25A40 (mitochondrial carrier) supports metabolic demands of proliferation. PPP1CC (protein phosphatase 1 gamma) regulates mitotic exit. TBC1D7 is part of the TSC1/TSC2 complex regulating mTOR and cell growth. Together these genes define a nuclear envelope and mitotic spindle program in proliferating DCs. Neighbor context: the most proliferation-specific module in this batch, complementing M20's RNA processing proliferation program.
Genes
Most correlated modules
- Focal Adhesion Remodeling · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.