Focal Adhesion Remodeling
Gene co-expression module in Dendritic cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 4 of 7 genes have a known function matching the annotation |
Why this annotation
VCL (vinculin, core focal adhesion protein linking integrins to actin cytoskeleton) and DEF6 (SWAP-70 homolog, Rho GEF involved in actin remodeling and immune cell migration) are the clearest cytoskeletal anchors. FLI1 (ETS transcription factor regulating myeloid and endothelial genes), DCAF12 (CRL4 ubiquitin ligase substrate receptor), ANAPC13 (APC/C ubiquitin ligase subunit), PIP4P2 (phosphoinositide phosphatase regulating PI(4,5)P2 at membranes, relevant to actin dynamics), and CCDC112 (coiled-coil domain protein) complete the module. The combination of VCL, DEF6, and PIP4P2 points to cytoskeletal/focal adhesion remodeling. The module is small (7 genes), uniformly expressed, and shows no significant disease association. Neighbor context (cDC2 identity modules M53, M8) suggests this may represent DC migration/adhesion machinery.
Genes
Most correlated modules
- Myeloid Inhibitory Receptors · correlation 0.92
- Tolerogenic DC State · correlation 0.90
- Gut-Homing DC · correlation 0.88
- cDC2 CLR Signaling · correlation 0.86
- Mitotic Nuclear Envelope · correlation 0.85
- TLR-MYD88 Signaling · correlation 0.85
- cDC2 Identity · correlation 0.84
- cDC2 Identity · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.