cDC1 Identity
Gene co-expression module in Dendritic cells
| Category | Development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
This moderate-coherence module shows enrichment in cDC1. Hub genes include LPP (lipoma preferred partner, cytoskeletal/focal adhesion), SLC9A9 (sodium-hydrogen exchanger, endosomal pH regulation), FLT3 (FMS-like tyrosine kinase 3, key DC development receptor), SPPL3 (signal peptide peptidase-like 3, glycoprotein processing), RAB11FIP4 (RAB11 family interacting protein, endosomal recycling), PDPK1 (PDK1, PI3K signaling), GCSAM (germinal center-associated signaling molecule, cDC1 marker), GNG7 (G-protein subunit), FLOT2 (flotillin-2, lipid raft/endocytosis), SELPLG (PSGL-1, selectin ligand, migration). FLT3 and GCSAM are canonical cDC1 markers. The module likely represents a cDC1 identity/development program. FLT3 drives cDC1 differentiation; GCSAM is selectively expressed in cDC1. The moderate coherence and mixed membership reflect the heterogeneous nature of this identity module.
Genes
Most correlated modules
- DC Maturation State · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.