DC Maturation State
Gene co-expression module in Dendritic cells
| Category | Development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 20 genes have a known function matching the annotation |
Why this annotation
This module has moderate coherence with no dominant subset enrichment. Hub genes include ZEB1 (zinc finger E-box binding homeobox, EMT/DC differentiation transcription factor), PTGES2 (prostaglandin E synthase 2, inflammatory lipid mediator), HLA-DOB (MHC-II non-classical, regulates peptide loading), REPIN1 (replication initiator), LSP1 (lymphocyte-specific protein 1, actin-binding, migration), VAC14 (PI(3,5)P2 synthesis, endolysosomal trafficking), DUSP4 (dual-specificity phosphatase, MAPK regulation), TRIB1 (tribbles pseudokinase, myeloid differentiation), RAB11A and RAB11FIP1 (recycling endosome trafficking), ZNF366 (DC-specific transcription factor/corepressor), NET1 (RhoA GEF, cytoskeletal), MAP4 (microtubule-associated), AUTS2 (transcriptional regulation). ZEB1 and ZNF366 are both DC differentiation/maturation transcription factors. RAB11A/RAB11FIP1 indicate recycling endosome activity. PTGES2 links to inflammatory lipid signaling. The combination of DC-specific TFs (ZEB1, ZNF366, TRIB1), recycling endosome genes, and cytoskeletal regulators suggests a DC maturation/differentiation state program. Neighbor M81 has mTOR/endosomal genes and M152 has MHC-II presentation, consistent with a DC maturation context. The treatment response (negative delta) suggests this program is reduced after treatment.
Genes
Most correlated modules
- MHC-I Antigen Presentation · correlation 0.82
- cDC1 Identity · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.