Lysosomal Lipid Catabolism
Gene co-expression module in Dendritic cells
| Category | Lysosomal & pahgocytosis |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 20 genes have a known function matching the annotation |
Why this annotation
ACP5 (TRAP, lysosomal acid phosphatase 5), CD68 (lysosomal/phagosomal marker), NPC2 (lysosomal cholesterol transporter), LIPA (lysosomal acid lipase), PLA2G7 (phospholipase/lipid catabolism), AXL (efferocytosis/phagocytosis receptor), MMP12 (matrix metalloproteinase), C1QA/C1QB (complement opsonization), CD207 (Langerin, endocytic receptor), FCMR (IgM Fc receptor for phagocytosis) collectively define a lysosomal/phagocytic lipid-processing program. The moderate coherence and uniform expression suggest this is a mixed module combining lysosomal catabolism and phagocytic uptake. Neighbor context: this module complements M116 (cDC2 identity) by capturing the phagocytic effector function of cDC2s.
Genes
Most correlated modules
- cDC2 Identity · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.