cDC2 Identity
Gene co-expression module in Dendritic cells
| Category | Development |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 16 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes MRC1, CSF1R, CLEC10A, CYBB, FCGR2A/B, CX3CR1, TLR2, NAIP, PILRA, IGSF6, PID1 are all canonical cDC2 identity markers. The module is core coherence, strongly enriched in cDC2 (up to 9.8x), and represents the transcriptional identity program of conventional type 2 dendritic cells in the gut. CD4 co-expression is consistent with gut cDC2s. No inflammatory activation signal; this is a steady-state identity module.
Genes
Most correlated modules
- cDC2 Identity · correlation 0.94
- cDC2 Identity · correlation 0.93
- cDC2 CLR Signaling · correlation 0.89
- cDC2 Identity · correlation 0.89
- Endosomal Trafficking · correlation 0.87
- Tolerogenic DC Signaling · correlation 0.85
- TLR-MYD88 Signaling · correlation 0.85
- Myeloid Inhibitory Receptors · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.