DC Migratory Antigen Processing
Gene co-expression module in Dendritic cells
| Category | Ag processing & presentation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 16 genes have a known function matching the annotation |
Why this annotation
LGMN (legumain) is a lysosomal cysteine endopeptidase with a well-established role in antigen processing and MHC-II loading. AP1S2 is a clathrin adaptor subunit (AP-1 sigma 2) involved in endosomal/lysosomal vesicular trafficking critical for antigen processing. ICAM3 mediates DC-T cell immunological synapse formation. SELL (CD62L) is a lymph node homing receptor expressed on migratory DCs. SIGIRR (TIR8) is a negative regulator of TLR and IL-1R signaling, associated with tolerogenic DC function. DDIT4 (REDD1) inhibits mTOR, which can promote lysosomal biogenesis and antigen processing. CD37 is a tetraspanin involved in MHC-II trafficking. P2RY14 is a purinergic receptor on DCs. The module is enriched in cDC1 and mDC, reduced by treatment, and shows moderate coherence. The combination of lysosomal antigen processing (LGMN), vesicular trafficking (AP1S2), DC-T contact (ICAM3), and homing (SELL) suggests migratory DCs with active antigen processing capacity. Neighbor context: shares lysosomal components with M114 (NAAA/LGMN) but is distinguished by migration/homing markers and antigen processing focus.
Genes
Most correlated modules
- Myeloid DC Identity · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.