Myeloid DC Identity
Gene co-expression module in Dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 15 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes AIF1 (Iba1), LY86, SAMHD1, CD53, and CD48 are canonical pan-myeloid identity markers. PYCARD (ASC) links to inflammasome assembly. CPVL, CST3, and RNASET2 are lysosomal/phagocytic components. VASP, GMFG, CORO1A, and CIB1 are actin cytoskeletal regulators. CYBA is the NADPH oxidase p22phox subunit. The module is uniformly expressed across DC subsets with strong coherence, indicating a core myeloid/DC housekeeping identity program rather than a specialized activation state. Neighbor context: M52 is the most broadly expressed module in this batch, consistent with a pan-myeloid baseline identity that underlies the more specialized programs in M114 and M58.
Genes
Most correlated modules
- Endosomal Retromer Trafficking · correlation 0.91
- G1/S Cell Cycle · correlation 0.88
- TLR-MYD88 Signaling · correlation 0.87
- Gut-Homing DC · correlation 0.85
- Tolerogenic DC State · correlation 0.85
- DC Migratory Antigen Processing · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.