Cytoskeletal Housekeeping
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 10 genes have a known function matching the annotation |
Why this annotation
ACTG1 and ACTB are the two major cytoplasmic actin isoforms, the most abundant cytoskeletal proteins. DYNLL1 is dynein light chain 1, involved in cytoskeletal motor function. HSPD1 (HSP60) and HSPE1 (HSP10) are mitochondrial matrix chaperonins. HSP90AB1 is cytosolic HSP90-beta. CACYBP is involved in ubiquitin-mediated degradation and actin dynamics. CYCS (cytochrome c) is a mitochondrial electron transport component. MRPL18 is a mitochondrial ribosomal protein. RBM8A is part of the exon junction complex. The module has the highest mean expression (1.524) and detection rate (77.2%) in the batch, consistent with broadly expressed housekeeping genes. Downregulation in inflammation likely reflects reduced overall cellular activity. The mix of cytoskeletal (ACTG1, ACTB, DYNLL1, CACYBP) and chaperone/mitochondrial genes suggests a general cellular maintenance/housekeeping program with cytoskeletal dominance.
Genes
Most correlated modules
- Intestinal Progenitor Identity · correlation 0.89
- Heat Shock Response · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.