Heat Shock Response
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
The module is dominated by heat shock proteins: HSP90AA1, HSPA1A, HSPA1B, HSPA8 (Hsp70 family), DNAJA1 (Hsp40 co-chaperone), and BAG1 (Hsp70 co-chaperone/nucleotide exchange factor). CLDN3 is a tight junction claudin marking epithelial identity. SELENOK is an ER-resident selenoprotein involved in protein quality control. The module is downregulated in inflammation and upregulated in remission, consistent with a proteostasis/chaperone program that is disrupted during inflammatory stress and restored in healthy epithelium. Neighbor M72 also shows a remission-associated protective program, supporting a shared homeostatic neighborhood.
Genes
Most correlated modules
- EGFR-mediated Repair · correlation 0.85
- Cytoskeletal Housekeeping · correlation 0.81
- NF-κB Secondary Response · correlation 0.69
- EGFR Wound Migration · correlation 0.66
- Immediate Early Response · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.