Intestinal Progenitor Identity
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Stemness |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 11 genes have a known function matching the annotation |
Why this annotation
KLF5 is the top hub gene and a master transcription factor for intestinal epithelial progenitor/stem cell identity and proliferation. UBE2D3 is a ubiquitin-conjugating enzyme involved in protein turnover. PAPOLA encodes poly(A) polymerase alpha, essential for mRNA 3' processing. SRSF3 is a splicing factor with roles in epithelial differentiation. PPP2CA is the catalytic subunit of PP2A phosphatase, regulating cell cycle and Wnt signaling. YTHDF2 is an m6A reader that promotes mRNA decay, regulating stem cell programs. SS18L2 and HNRNPA0 are chromatin/RNA regulators. MAP3K13 is a kinase in NF-κB/Wnt pathways. The module is significantly downregulated in both UC and CD inflammation and restored in remission, consistent with a progenitor/stem cell identity program suppressed during active disease. KLF5's centrality and the disease response pattern strongly support an intestinal progenitor identity label.
Genes
Most correlated modules
- RNA Processing Translation · correlation 0.91
- ER Membrane Organization · correlation 0.89
- Cytoskeletal Housekeeping · correlation 0.89
- Housekeeping Transcription · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.