Absorptive Colonocyte Differentiation
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | absorptive cell development |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 8 genes have a known function matching the annotation |
Why this annotation
MYO1A is a canonical brush border myosin expressed in mature absorptive colonocytes; CES2 is a carboxylesterase highly enriched in differentiated colonocytes; SIAE modifies sialic acid on epithelial glycans; GSS provides glutathione-based antioxidant capacity in mature epithelium; TTLL12 modifies tubulin in differentiated cells; DCK and FARSB support nucleoside/amino acid metabolism in active absorptive cells. The module is strongly and significantly decreased in both UC and CD inflammation and restored in remission, a hallmark of differentiated colonocyte programs lost during mucosal injury. STEAP1 (metalloreductase) also fits absorptive cell iron handling. Together these genes reflect a mature absorptive colonocyte differentiation program.
Genes
Most correlated modules
- Actin Cytoskeletal Dynamics · correlation 0.84
- Protein Glycosylation · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.