Protein Glycosylation
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes GFPT1 (rate-limiting hexosamine biosynthesis enzyme feeding UDP-GlcNAc), GALNT1 (O-GalNAc transferase initiating mucin-type glycosylation), STT3B (N-glycosylation catalytic subunit), SLC39A7 (ER zinc transporter supporting glycosylation enzymes), and CLTC/CLINT1 (clathrin-mediated vesicular trafficking of glycoproteins) collectively define a protein glycosylation and vesicular trafficking program. GSR and DDAH1 provide metabolic/redox support. Neighbor M4 (epithelial adhesion with CANX glycoprotein chaperone) and M61 (Golgi secretory processing) reinforce a glycoprotein biosynthesis neighborhood.
Genes
Most correlated modules
- Epithelial Cell Adhesion · correlation 0.92
- ER Protein Translocation · correlation 0.87
- Actin Cytoskeletal Dynamics · correlation 0.86
- Mitochondrial Cristae Organization · correlation 0.85
- Cytoskeletal Junction · correlation 0.85
- Metabolic Housekeeping · correlation 0.85
- Mitochondrial OxPhos · correlation 0.84
- ER Stress UPR · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.