Actin Cytoskeletal Dynamics
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
Top hub gene WASL (N-WASP) drives actin nucleation and cytoskeletal remodeling; RAP1A is a small GTPase regulating cell adhesion and cytoskeletal dynamics; MZT1 is a γ-TuRC component for microtubule nucleation. Secondary genes TMED7, COPB1, and SNX6 reflect vesicle/membrane trafficking. NFE2L2 (NRF2) and PRKACB add stress-response and signaling context. The module is a neighbor to M54 (housekeeping/chromatin), and both share uniform low expression and disease-response patterns consistent with general cellular maintenance. The dominant cytoskeletal signal from WASL, RAP1A, and MZT1 anchors the label.
Genes
Most correlated modules
- Protein Glycosylation · correlation 0.86
- Absorptive Colonocyte Differentiation · correlation 0.84
- Nuclear Housekeeping · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.