Colonocyte Differentiation
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | absorptive cell development |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
CHP2 is a calcineurin B homologous protein that activates NHE3 (Na+/H+ exchanger), a defining feature of mature colonocyte ion transport. LGALS4 (galectin-4) is a well-established colonocyte differentiation marker enriched in the brush border. PHGR1 is a proline/histidine/glycine-rich protein expressed specifically in colonocyte brush border. ADH1C and UGT2A3 are phase I/II xenobiotic metabolism enzymes characteristic of differentiated colonocytes. DHRS11 is a short-chain dehydrogenase expressed in colonocytes. C15orf48 is mitochondria-associated and expressed in colonocytes. CWH43 remodels GPI anchors on the apical surface. TSPAN7 is a tetraspanin. The module is dramatically downregulated in both UC and CD inflammation and recovers strongly in remission, consistent with loss of colonocyte differentiation in active IBD. Neighbor M58 is a parallel mature colonocyte module, together defining the differentiated absorptive colonocyte transcriptional state.
Genes
Most correlated modules
- Mitochondrial Fatty Acid Oxidation · correlation 0.84
- Absorptive Colonocyte Function · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.