Mitochondrial Fatty Acid Oxidation
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
All hub genes are mitochondrial metabolic enzymes: HADHA (mitochondrial trifunctional protein alpha subunit, long-chain fatty acid beta-oxidation), SUCLG2 (succinyl-CoA ligase beta subunit, TCA cycle), NDUFS1 (NADH dehydrogenase Fe-S protein 1, Complex I/OxPhos), ACAT1 (acetyl-CoA acetyltransferase, ketone body/FA metabolism), MAOA (monoamine oxidase A, mitochondrial outer membrane). CAT (catalase) handles reactive oxygen species from mitochondrial metabolism. NCOA4 mediates ferritinophagy supporting iron availability for mitochondrial enzymes. PGM1 links glycogen to glycolysis/mitochondrial input. SLC44A1 transports choline for mitochondrial membrane phospholipids. Strongly downregulated in both UC and CD inflammation with recovery upon treatment — consistent with loss of colonocyte mitochondrial function in IBD. Neighbor M73 also contains mitochondrial genes (IMMT, IARS2, CS), reinforcing this neighborhood as a mitochondrial metabolism cluster.
Genes
Most correlated modules
- Oxidative Phosphorylation · correlation 0.92
- Epithelial Cell Adhesion · correlation 0.90
- Mitochondrial Cristae Organization · correlation 0.88
- Golgi Secretory Processing · correlation 0.85
- Colonocyte Differentiation · correlation 0.84
- Protein Glycosylation · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.