Mast Cell Identity
Gene co-expression module in Mast cells
| Category | Mast cell development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 27 genes have a known function matching the annotation |
Why this annotation
Hub genes include MS4A4A (MS4A family, expressed on mast cells and macrophages), FPR3 (formyl peptide receptor 3, innate immune pattern recognition, expressed on mast cells/monocytes), CADM1 (cell adhesion molecule 1, critical for mast cell identity, tissue retention, and IgE receptor signaling), IGSF3 (immunoglobulin superfamily member 3), ABCB1 (MDR1/P-glycoprotein, drug efflux transporter), GLIPR1 (immune modulator/tumor suppressor), RGS5 (regulator of G-protein signaling), MMP7 (matrix metalloprotease 7), MINDY3 (deubiquitinase). CADM1, MS4A4A, and FPR3 are strong mast cell identity markers. CADM1 in particular is a defining mast cell surface molecule. This module represents mast cell identity with innate immune sensing capacity.
Genes
Most correlated modules
- Transcriptional Regulation · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.