Transcriptional Regulation
Gene co-expression module in Mast cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 21 genes have a known function matching the annotation |
Why this annotation
Hub genes include MLLT3 (chromatin/epigenetic regulator, part of DOT1L complex), MRFAP1L1 (MORF4L1-associated, chromatin), ZBTB38 (transcriptional repressor), S1PR1 (sphingosine-1-phosphate receptor 1, regulates immune cell trafficking and mast cell retention), PRICKLE1 (Wnt/PCP pathway), PAN2 (poly(A) nuclease, mRNA deadenylation), INPP4B (inositol phosphatase, PI signaling), TBC1D10A and TBC1D17 (RAB-GAPs, vesicle trafficking). The module is loosely coherent with a mix of transcriptional regulation, lipid/PI signaling, and trafficking. S1PR1 is notable for mast cell tissue retention/egress. The overall program resembles a broad regulatory/homeostatic module without a dominant single pathway.
Genes
Most correlated modules
- NF-κB Signaling · correlation 0.86
- Mast Cell Identity · correlation 0.86
- TGF-beta Tolerance · correlation 0.85
- Mast Cell Identity · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.