Post-transcriptional Regulation
Gene co-expression module in Mast cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 28 genes have a known function matching the annotation |
Why this annotation
This module contains a heterogeneous set of genes with uniform low expression (~10% positive cells) and unknown coherence. Hub genes include MGA (transcriptional repressor, MAX dimerization), TTC17 (ciliogenesis), ST6GAL1 (sialylation enzyme), NCBP1 (nuclear cap-binding protein, mRNA processing), RC3H2 (RNA-binding, mRNA decay), MARF1 (mRNA regulation), DICER1 (miRNA biogenesis), RPRD2 (RNA Pol II regulation), and CASP3 (apoptosis). The module is enriched for post-transcriptional and RNA regulatory factors (NCBP1, RC3H2, MARF1, DICER1, RPRD2) alongside large scaffold proteins (FRY, EML3, KLHL9). TSC1 links to mTOR signaling. The delta_remission_UC of -0.337 suggests mild downregulation in remission. The overall picture is a loosely co-expressed set of genes involved in RNA processing and post-transcriptional regulation, with some apoptotic and signaling components. The RNA processing theme is the most coherent thread.
Genes
Most correlated modules
- Mast Cell Progenitor · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.