Mast Cell Progenitor
Gene co-expression module in Mast cells
| Category | Mast cell development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 25 genes have a known function matching the annotation |
Why this annotation
Hub genes PRSS57 (hematopoietic serine protease expressed in neutrophil/mast cell progenitors), IL3RA (CD123, IL-3 receptor alpha, highly expressed on basophils and mast cell progenitors), NFE2 (p45, transcription factor critical for megakaryocyte/erythroid/mast cell development), POU2F2 (Oct-2, hematopoietic transcription factor), IKZF2 (Helios, lymphoid/mast cell transcription factor), CDK6 (cell cycle kinase active in progenitors), TFRC (CD71, transferrin receptor, proliferating progenitors), CXCL2/CXCL3 (inflammatory chemokines), ABO (blood group glycosyltransferase, expressed in hematopoietic cells), MGST1 (glutathione transferase). The combination of IL3RA, NFE2, PRSS57, IKZF2, and CDK6 strongly points to a hematopoietic/mast cell progenitor program. Very low expression consistent with rare progenitor cells.
Genes
Most correlated modules
- Post-transcriptional Regulation · correlation 0.84
- S-phase Histones · correlation 0.72
- Histone Ubiquitination · correlation 0.60
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.