Actin-microtubule remodeling
Gene co-expression module in Monocytes
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 41 genes have a known function matching the annotation |
Why this annotation
Low-detection module (22%) enriched for cytoskeletal regulators: SEPTIN11, DAAM1, TUBB6, GAS2L1, SPIRE1, TAGLN2 and EMP1. It also carries ciliary/epithelial-type genes (SPEF2, DYNC2I1, CEP126, PKP2, SERPINI2) and CALCRL. The cytoskeletal remodeling component is plausible in activated or migrating monocytes. The epithelial/ciliary genes suggest some ambient or doublet contribution.
Genes
Most correlated modules
- RFX-associated transcription · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.