AP-1 Stress Response
Gene co-expression module in Monocytes
| Category | Stress |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes FOSB (AP-1 immediate-early), RGS2 (stress/cAMP-induced GTPase regulator), BTG2 (anti-proliferative stress gene), PPP1R15B (GADD34, eIF2α phosphatase regulator), PMAIP1 (NOXA, pro-apoptotic BH3-only), WSB1 (hypoxia-inducible E3 ligase), PLK3 (stress-activated kinase) collectively define an AP-1-driven immediate-early stress response program. Upregulated in inflammation, downregulated in remission. Neighbor to M36 (NR4A immediate-early) and M82/M26 (heat shock), consistent with a coordinated stress-inflammatory activation neighborhood.
Genes
BTG2, FOSB, MYLIP, PLK3, PMAIP1, PPP1R10, PPP1R15B, RGS2, VMP1, WSB1
Most correlated modules
- Inflammatory Stress Response · correlation 0.88
- IRF1 Innate Activation · correlation 0.86
- NR4A Immediate-Early · correlation 0.78
- Heat Shock Response · correlation 0.78
- Epigenetic Inflammatory Reprogramming · correlation 0.76
- Immediate-Early Inflammatory · correlation 0.75
- Monocyte Activation State · correlation 0.74
- Inflammasome Activation · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.