Resting monocyte identity
Gene co-expression module in Monocytes
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
These are highly expressed, broadly detected genes. They include MHC class I (HLA-A, HLA-B), CD4, IL10RA, TXNIP, ITM2B and MALT1, which are typical high-abundance monocyte transcripts. HLA-A, HLA-B, MALT1 and ITM2B are weak members, consistent with a moderate-coherence module. This reads as a resting classical monocyte identity/quiescence program; TXNIP marks the quiescent state and IL10RA reflects regulatory signaling.
Genes
Most correlated modules
- MHC-II antigen presentation · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.