MHC-II antigen presentation
Gene co-expression module in Monocytes
| Category | Adaptive immunity |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 27 genes have a known function matching the annotation |
Why this annotation
The hubs and core members are CIITA, HLA-DMB, IRF8, TAPBP, BTN2A2, TLR7, FGL2 and ADA2. This is the CIITA/IRF8-driven MHC class II antigen-presentation program. Together with TLR7 and IRF8, it suggests monocyte-to-DC/macrophage differentiation. Several hubs (CAMK2D, ITPRIPL2, TMEM106A, NUP62) are less specific, but the module is strongly coherent with a clear MHC-II core. The neighbors are generic monocyte state modules, which leaves this as the best-defined antigen-presentation axis in the batch.
Genes
Most correlated modules
- Lysosomal autophagy · correlation 0.87
- Antiviral restriction factors · correlation 0.80
- WASH endosomal recycling · correlation 0.78
- Basal endolysosomal maintenance · correlation 0.77
- Resting monocyte identity · correlation 0.75
- IFN-induced antiviral autophagy · correlation 0.72
- Inflammatory CXCL10+ monocytes · correlation 0.69
- IFN-gamma response · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.