MAPK inflammatory activation
Gene co-expression module in Monocytes
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 15 of 32 genes have a known function matching the annotation |
Why this annotation
Activation genes CD83, EGR2, EGR3, PTGS2, NAMPT, RIPK2, MAPKAPK2, TRIB1, DUSP2 and DUSP6 appear alongside JUNB, ZFP36 and BTG2. This represents an IEG-overlapping MAPK/NF-kB inflammatory activation program in monocytes. It neighbors the dissociation module M128, but PTGS2, CD83 and NAMPT suggest genuine TLR/NOD-driven activation.
Genes
Most correlated modules
- NF-kB signaling · correlation 0.71
- Basal transcription/splicing · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.