NF-κB Counter-regulation
Gene co-expression module in Monocytes
| Category | Inflammatory |
|---|---|
| Genes | 8 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
IL1RN (IL-1Ra) is a canonical anti-inflammatory cytokine. TNIP3 and TNFAIP8 are NF-κB negative regulators. CD274 (PD-L1) is an immune checkpoint molecule upregulated on activated monocytes. GPR84 is a pro-inflammatory lipid receptor on myeloid cells. RHOH and ABL2 modulate immune signaling. C15orf48 is associated with inflammatory responses. The module represents NF-κB negative feedback and checkpoint induction — a counter-regulatory inflammatory program in monocytes during IBD.
Genes
ABL2, C15orf48, CD274, GPR84, IL1RN, RHOH, TNFAIP8, TNIP3
Most correlated modules
- TNF/IL-1 Cytokine Storm · correlation 0.93
- Monocyte Chemokine Secretion · correlation 0.87
- Tolerogenic Monocyte Activation · correlation 0.86
- SPP1+ Inflammatory Macrophage · correlation 0.85
- TNF-driven Activation · correlation 0.83
- IRF1 Innate Activation · correlation 0.82
- NF-κB Signaling · correlation 0.82
- Inflammatory Stress Response · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.