Pentose Phosphate Pathway
Gene co-expression module in Monocytes
| Category | Innate immunity |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes G6PD and PGD encode the first two enzymes of the pentose phosphate pathway (PPP), generating NADPH and ribose-5-phosphate. FLOT2 (lipid raft scaffolding), DYSF (membrane repair), NBEAL2 (granule biogenesis), ACAP1 (endosomal Arf-GAP), and RAB5IF (Rab5 effector) support a membrane/vesicular context. CCND3 suggests cell cycle entry. The PPP is critical for NADPH-dependent oxidative burst in monocytes. Decreased in remission, trending up in inflammation. The dominant metabolic theme is pentose phosphate/redox metabolism supporting myeloid activation.
Genes
ACAP1, AP5B1, CCDC69, CCND3, CITED4, CORO2A, DYSF, EIF4E3, FLOT2, G6PD, NBEAL2, PGD, RAB5IF
Most correlated modules
- Myeloid Activation · correlation 0.84
- Classical Monocyte Trafficking · correlation 0.78
- Granulocytic Differentiation · correlation 0.78
- Multi-lineage Contamination · correlation 0.77
- p38 MAPK Signaling · correlation 0.75
- Leukotriene-Alarmin Response · correlation 0.75
- Classical Monocyte Activation · correlation 0.72
- Histone Chromatin Remodeling · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.