NF-kB feedback regulation
Gene co-expression module in Monocytes
| Category | Innate immunity |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 22 genes have a known function matching the annotation |
Why this annotation
Hub IL15 together with TRIM38, TRAFD1, CYLD and VCPIP1 points to NF-kB/IFN regulatory signalling. BAZ1A, BACH1, SMAD3, SOS1 and SPPL2A are broadly expressed regulators. Expression is uniform with high detection. This reads as a weak, tonic innate-signalling and negative-feedback program in monocytes rather than a sharp activation state. It shares low-amplitude IFN/innate-regulation genes with neighbor M77 (TRIM25, SP100).
Genes
Most correlated modules
- Chromatin transcription regulators · correlation 0.89
- IFN-induced antiviral autophagy · correlation 0.84
- Monocyte innate sensing · correlation 0.81
- Membrane trafficking housekeeping · correlation 0.79
- WASH endosomal recycling · correlation 0.78
- Tonic interferon signaling · correlation 0.76
- IFN-gamma response · correlation 0.72
- Type I Interferon · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.