RNA Splicing Stress
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
This small module has all weak memberships and unknown coherence. PTPRCAP (CD45-associated protein, lymphocyte signaling), U2AF1 (RNA splicing factor), H2BC12 (histone H2B, chromatin/replication), MATR3 (nuclear matrix protein, RNA processing), SIK1 (salt-inducible kinase, stress/metabolic signaling), BOLA2-SMG1P6 (iron-sulfur cluster assembly/NMD-related), ZC3H11A (zinc finger RNA-binding, stress response), GPR171 (G-protein coupled receptor, lymphocyte homing). The module is heterogeneous and weakly defined. The combination of RNA splicing (U2AF1, MATR3, ZC3H11A), histone (H2BC12), and lymphocyte markers (PTPRCAP, GPR171) does not resolve into a single clean program. The neighbor context (M36 is a mixed cycling/monocyte module) suggests these modules co-vary in a poorly defined cell state. The RNA processing genes (U2AF1, MATR3, ZC3H11A) are the most coherent sub-theme, pointing toward RNA splicing/processing as the dominant program, possibly a stress-related RNA processing response.
Genes
Most correlated modules
- Lymphomyeloid Progenitor · correlation 0.47
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.