Plasmacytoid dendritic cells: gene co-expression modules

Rare lymphoid-like dendritic cells sensing nucleic acids through endosomal TLR7 and TLR9; they secrete copious type I interferon, driving antiviral defence and, when dysregulated, autoimmunity.

SCUBA's reference network for Plasmacytoid dendritic cells holds 142 gene modules covering 2,912 genes. Each module is a group of genes that rise and fall together across these cells, annotated with the biological process it most likely represents.

View the Plasmacytoid dendritic cells network in SCUBA

Ag processing & presentation (4)

• Immunoproteasome Response · 0 genes
• Lysosomal Ag Processing · 0 genes
• MHC Class II Presentation · 0 genes
• MHC-I Presentation · 0 genes

Antiviral (11)

• Antiviral Innate Sensing · 0 genes
• Endosomal Innate Sensing · 0 genes
• IFN Receptor Signaling · 0 genes
• IFN-Vesicular Response · 0 genes
• Innate Antiviral Sensing · 0 genes
• pDC Innate Sensing · 0 genes
• Type I Interferon · 0 genes
• Type I Interferon · 0 genes
• Type I Interferon · 0 genes
• Type I Interferon · 0 genes
• Type I Interferon · 0 genes

Cytoskeletal (6)

• Actin Cytoskeletal Remodeling · 0 genes
• Actin Cytoskeleton · 0 genes
• Actin Cytoskeleton · 0 genes
• Actin Cytoskeleton · 0 genes
• Autophagy Cytoskeletal · 0 genes
• Centrosome Organization · 0 genes

Development (8)

• DC Maturation Migration · 0 genes
• Hematopoietic Development · 0 genes
• Lymphomyeloid Progenitor · 0 genes
• Myeloid Differentiation · 0 genes
• pDC Identity · 0 genes
• pDC Identity & Splicing · 0 genes
• pDC Identity Signaling · 0 genes
• Progenitor Transcription · 0 genes

Housekeeping (63)

• Cell Cycle Regulation · 0 genes
• Chromatin & Ubiquitin · 0 genes
• Chromatin Regulation · 0 genes
• Chromatin Remodeling · 0 genes
• Chromatin Remodeling · 0 genes
• Chromatin Remodeling · 0 genes
• Chromatin RNA Regulation · 0 genes
• Cilia & Centrosome · 0 genes
• DNA Repair & Chromatin · 0 genes
• DNA Repair Housekeeping · 0 genes
• Epigenetic Regulation · 0 genes
• Epigenetic Regulation · 0 genes
• Epigenetic Regulation · 0 genes
• Epigenetic Silencing · 0 genes
• ER Protein Folding · 0 genes
• ER Protein Folding · 0 genes
• ER Redox Homeostasis · 0 genes
• General Cellular Maintenance · 0 genes
• General Housekeeping · 0 genes
• Genome Organization · 0 genes
• Glycolytic Metabolism · 0 genes
• Intracellular Kinase Signaling · 0 genes
• Kinase Phosphatase Signaling · 0 genes
• Low-coherence Background · 0 genes
• Low-coherence Background · 0 genes
• Low-coherence Background · 0 genes
• Low-coherence Background · 0 genes
• Low-coherence Background · 0 genes
• Low-coherence Background · 0 genes
• Lysosomal mTOR Signaling · 0 genes
• Metabolic Housekeeping · 0 genes
• Metabolic Housekeeping · 0 genes
• Mixed Housekeeping · 0 genes
• Mixed Housekeeping · 0 genes
• Mixed Housekeeping · 0 genes
• Mixed Housekeeping · 0 genes
• Mixed Maintenance Genes · 0 genes
• Mixed Regulatory · 0 genes
• Mixed Regulatory · 0 genes
• Mixed Regulatory Background · 0 genes
• Mixed Regulatory Background · 0 genes
• Mixed Regulatory Background · 0 genes
• Mixed Regulatory Background · 0 genes
• Mixed Signaling · 0 genes
• Mixed Signaling Regulation · 0 genes
• Polycomb Transcription · 0 genes
• Post-transcriptional Regulation · 0 genes
• RNA Processing · 0 genes
• RNA Processing · 0 genes
• RNA Processing · 0 genes
• RNA Processing Regulation · 0 genes
• RNA Splicing Regulation · 0 genes
• Survival & Adhesion · 0 genes
• Transcription & Splicing · 0 genes
• Transcription Regulation · 0 genes
• Transcriptional Coactivation · 0 genes
• Transcriptional Regulation · 0 genes
• Transcriptional Regulation · 0 genes
• Transcriptional Repression · 0 genes
• Translation Initiation · 0 genes
• Ubiquitin Proteasome · 0 genes
• Ubiquitin-Proteasome Regulation · 0 genes
• Zinc Finger Transcription · 0 genes

Inflammatory (8)

• Inflammatory Activation · 0 genes
• Innate Myeloid Effector · 0 genes
• JAK-STAT Signaling · 0 genes
• Lipid Metabolic Reprogramming · 0 genes
• NF-κB Immune Signaling · 0 genes
• pDC Activation Response · 0 genes
• TGF-beta Survival · 0 genes
• TLR Signaling Regulation · 0 genes

Migration & adhesion (6)

• Chemokine Migration Response · 0 genes
• CX3CR1 Migration · 0 genes
• Immune Cell Migration · 0 genes
• Monocyte Chemotaxis · 0 genes
• Rho GEF Migration · 0 genes
• Rho GEF Signaling · 0 genes

Mitochondrial & OxPhos (8)

• ATP Synthase Complex · 0 genes
• ATP Synthase F1 · 0 genes
• Complex I Assembly · 0 genes
• Complex I Subunits · 0 genes
• Mitochondrial Assembly · 0 genes
• Mitochondrial Import · 0 genes
• Mitochondrial Ribosome · 0 genes
• Respiratory Chain · 0 genes

Other (1)

• M18 · 0 genes

Proliferation (5)

• Cell Cycle Regulation · 0 genes
• Cell Cycle Regulation · 0 genes
• Centrosome DNA Damage · 0 genes
• Histone Expression · 0 genes
• Mitotic Cell Cycle · 0 genes

Stress (12)

• DNA Damage Response · 0 genes
• DNA Damage Response · 0 genes
• DNA Damage Response · 0 genes
• Glucocorticoid Receptor · 0 genes
• Glucocorticoid Stress Response · 0 genes
• Heat Shock Response · 0 genes
• Metabolic Stress Response · 0 genes
• Oxidative Stress Response · 0 genes
• RNA Splicing Stress · 0 genes
• Stress & Apoptotic Priming · 0 genes
• Stress Kinase Signaling · 0 genes
• Transcriptional Stress Response · 0 genes

Vesicular traficking (10)

• ARF-mediated Trafficking · 0 genes
• Autophagy & Proteostasis · 0 genes
• Clathrin-mediated Endocytosis · 0 genes
• Endosomal Trafficking · 0 genes
• ER Quality Control · 0 genes
• ER-Golgi Trafficking · 0 genes
• ER-Golgi Trafficking · 0 genes
• Fc Receptor Trafficking · 0 genes
• Lipid Transport & Membrane · 0 genes
• Vesicular Immune Signaling · 0 genes