Lymphomyeloid Progenitor
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Development |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 19 genes have a known function matching the annotation |
Why this annotation
OSCAR is an osteoclast/myeloid-associated receptor; HLX is a hematopoietic transcription factor; IL7R marks lymphoid progenitors and some pDC subsets; CSRP1 and BASP1 are cytoskeletal/differentiation-associated; TNFRSF25 mediates apoptosis/immune signaling; SESN3 is a stress-response sestrin. The module is highly heterogeneous with weak coherence across all genes, suggesting a loosely co-expressed set of genes at the myeloid-lymphoid developmental interface, possibly reflecting pDC progenitor states.
Genes
Most correlated modules
- Myeloid Differentiation · correlation 0.64
- IFN-Vesicular Response · correlation 0.59
- Progenitor Transcription · correlation 0.56
- Glycolytic Metabolism · correlation 0.55
- Survival & Adhesion · correlation 0.54
- Hematopoietic Development · correlation 0.49
- Innate Myeloid Effector · correlation 0.47
- RNA Splicing Stress · correlation 0.47
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.