Mitotic Spindle
Gene co-expression module in Plasma cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 18 of 25 genes have a known function matching the annotation |
Why this annotation
Hub genes TOP2A (decatenation of chromosomes, late G2/M), UBE2C (APC/C E2, anaphase), AURKA/AURKB (aurora kinases, mitotic spindle and chromosome segregation), TPX2 (spindle assembly, AURKA activator), GTSE1 (microtubule stabilization in anaphase), ASPM (spindle pole), CCNB1 (cyclin B1, M-phase cyclin), CDC20 (APC/C activator, metaphase-anaphase), CENPF/CENPE (kinetochore), KIF20B (cytokinesis kinesin), MKI67 (mitosis marker), NUSAP1 (spindle microtubule), CDK1 (master mitotic kinase), AURKB (chromosomal passenger complex), CDCA3 (Emi2/Tome-1, APC/C regulator), SGO2 (shugoshin, centromere protection), CKAP2 (spindle). This is a canonical late mitosis / mitotic spindle module. Strong coherence, very high plasmablast enrichment, significant inflammation association. Neighbor context confirms placement in a cluster of plasmablast cell-cycle modules.
Genes
Most correlated modules
- Spindle Assembly Checkpoint · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.