Spindle Assembly Checkpoint
Gene co-expression module in Plasma cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes PTTG1 (securin, APC/C substrate degraded at metaphase-anaphase transition), CKS1B (CDK regulatory subunit, mitotic), CDKN3 (CDK phosphatase active in mitosis), BIRC5 (survivin, chromosomal passenger complex, mitosis), MAD2L1 (spindle assembly checkpoint), BUB1/BUB3 (spindle assembly checkpoint kinases), PHF19 (PRC2 associated, expressed in proliferating cells), CENPW (kinetochore), RAD21 (cohesin, cleaved at anaphase), SKA2 (kinetochore-microtubule attachment), HMGB3 (chromatin, mitosis), MZT1 (gamma-TuRC, spindle pole). This module captures the spindle assembly checkpoint and metaphase-to-anaphase transition. Significant inflammation association in both UC and CD. Neighbor context: sits between G2/M entry (M26) and late mitosis/cytokinesis (M41), consistent with metaphase checkpoint.
Genes
Most correlated modules
- Mitotic Entry G2/M · correlation 0.97
- Mitotic Spindle · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.