Chaperone-mediated Proteostasis
Gene co-expression module in Tuft cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
HSP90AB1 (cytosolic HSP90-beta), HSPE1 (HSP10/co-chaperone for mitochondrial folding), TCP1 (CCT1 chaperonin subunit), PTGES3 (p23 co-chaperone for HSP90 and prostaglandin E synthase 3) form a dominant chaperone/proteostasis cluster. BTG3 (anti-proliferative BTG family, promotes cell cycle exit and differentiation) and ARID5B (transcription factor driving epithelial differentiation) indicate fate commitment. CLDN3 (claudin-3, tight junction barrier) marks epithelial maturation. MRPL18 (mitoribosome) and AHNAK (scaffold for membrane repair/signaling) are supporting members. The module reflects proteostasis maintenance during tuft cell fate commitment, with chaperones supporting protein folding as cells exit the cell cycle and differentiate.
Genes
Most correlated modules
- Tuft Cytoskeletal Remodeling · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.