Tuft Cytoskeletal Remodeling
Gene co-expression module in Tuft cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes EZR (ezrin, canonical tuft marker and cytoskeletal linker), YWHAH (14-3-3 signaling scaffold), CCT4 (chaperonin/cytoskeletal folding), NET1 (RhoA GEF), RAB11FIP1 (endosomal recycling), CANX (ER chaperone), DNAJA1/HSPA8 (HSP40/70 chaperones) collectively point to cytoskeletal organization and membrane/vesicle trafficking during pre-tuft differentiation. EZR is a defining tuft cell marker. The module reflects cytoskeletal remodeling and protein folding support during tuft cell fate acquisition.
Genes
Most correlated modules
- Chaperone-mediated Proteostasis · correlation 0.93
- Translation Initiation · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.