MHC II Antigen Presentation
Gene co-expression module in Tuft cells
| Category | Inflamation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
Five MHC class II genes (HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRA, HLA-DRB1) and their chaperone CD74 dominate this module. LGALS1 and VIM are immunomodulatory/mesenchymal-associated. The module is significantly upregulated in UC inflammation and enriched in pre_tuft cells. This represents MHC class II antigen presentation capacity in tuft/pre-tuft epithelial cells, induced by IFN-γ during inflammation — consistent with the neighboring M19 interferon module.
Genes
Most correlated modules
- Tuft Secretory Processing · correlation 0.24
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.