Tuft Secretory Processing
Gene co-expression module in Tuft cells
| Category | Secretion |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 13 genes have a known function matching the annotation |
Why this annotation
PLAC8 is a well-established tuft cell marker in the intestine. ACSL4 (acyl-CoA synthetase long chain family member 4) activates arachidonic acid for eicosanoid/lipid mediator synthesis, linking to tuft cell lipid biology. RAB37 mediates vesicle trafficking and secretion. FURIN is a proprotein convertase involved in processing secreted proteins. MAN2A1 is a Golgi mannosidase involved in glycoprotein processing. CORO2B (coronin 2B) regulates actin dynamics. DPYSL2 (CRMP2) is a cytoskeletal/axon guidance protein. ISG15 is an interferon-stimulated ubiquitin-like modifier, possibly reflecting tuft-immune interface. CCDC88B (GIV/Girdin) is a Gα-interacting protein involved in GPCR signaling. SNRNP27 is an RNA splicing factor. NCMAP and KLHDC7A are less characterized. MYEOV is associated with cell proliferation. The module combines tuft identity (PLAC8), lipid metabolism (ACSL4), and secretory/vesicle trafficking (RAB37, FURIN, MAN2A1), suggesting tuft cell secretory lipid processing.
Genes
Most correlated modules
- Eicosanoid Inflammatory Modulation · correlation 0.90
- Tuft Chemosensory Transduction · correlation 0.84
- Tuft Lipid Secretion · correlation 0.80
- Type I Interferon · correlation 0.74
- Lipid Metabolite Transport · correlation 0.70
- Tuft GPCR Signaling · correlation 0.65
- Tuft Cell Identity · correlation 0.60
- Cholinergic Tuft Signaling · correlation 0.55
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.