EGF Ligand Inflammatory
Gene co-expression module in Tuft cells
| Category | Inflamation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes include HBEGF and EREG (EGF receptor ligands), CXCL2 (chemokine, neighbor to CXCL1/3 in M52), TRIB1 (tribbles-1, activates inflammatory MAPK/NF-κB), EDN1 (endothelin-1, inflammatory vasoactive peptide), ID1 (BMP-induced inhibitor of differentiation), PHLDA2 (stress/inflammatory response), and OTUD1 (deubiquitinase modulating inflammatory signaling). All strongly enriched in pre_tuft. This module captures EGF ligand secretion coupled with inflammatory mediator production in pre-tuft cells, complementing the chemokine-dominant M52 in the same neighborhood.
Genes
Most correlated modules
- Chemokine Secretion Program · correlation 0.98
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.