Chemokine Secretion Program
Gene co-expression module in Tuft cells
| Category | Inflamation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
Dominated by chemokines CXCL1, CXCL3, and CCL20, alongside GDF15 (stress-induced inflammatory cytokine), ZFP36L1 (AU-rich element mRNA decay factor regulating inflammatory transcripts), EPHA2 (inflammatory signaling), and RHOV (Rho GTPase linked to inflammatory cytoskeletal remodeling). All genes are strongly enriched in pre_tuft cells. This module represents an inflammatory chemokine secretion program in pre-tuft cells, neighboring M80 which shares CXCL2 and additional inflammatory mediators, confirming a coherent inflammatory neighborhood.
Genes
Most correlated modules
- EGF Ligand Inflammatory · correlation 0.98
- Pre-tuft WNT Secretion · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.