WNT Progenitor State
Gene co-expression module in Tuft cells
| Category | WNT pathway |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 10 genes have a known function matching the annotation |
Why this annotation
TCF7L2 is the top-ranked transcription factor and a canonical WNT/beta-catenin target driving intestinal progenitor identity. MCM7 supports a proliferative/replication program. HNRNPAB contributes RNA processing capacity. P4HB and ENTPD5 reflect ER protein folding/glycosylation supporting high secretory output. SLC12A2 (NKCC1) is an ion cotransporter active in secretory progenitors. POLR1D (RNA Pol I) indicates active ribosome biogenesis. VDR and SOD2 add anti-inflammatory and oxidative defense context. All genes are enriched in pre_tuft. The module is best characterized as a WNT-driven progenitor transcriptional program, consistent with pre-tuft cells maintaining TCF7L2-dependent progenitor identity before terminal tuft differentiation. As a topological neighbor of M21, both modules co-activate in pre-tuft cells, with TCF7L2 potentially regulating metabolic/transport genes in M21.
Genes
Most correlated modules
- Progenitor Metabolic Reprogramming · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.