Progenitor Metabolic Reprogramming
Gene co-expression module in Tuft cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 16 of 16 genes have a known function matching the annotation |
Why this annotation
APEX1 (apurinic endonuclease, base excision repair and redox regulation), OVOL1 (epithelial transcription factor driving differentiation), AHCY (S-adenosylhomocysteine hydrolase, one-carbon/methylation metabolism), IMPDH2 (IMP dehydrogenase, purine biosynthesis), CYCS (cytochrome c, mitochondrial), CKB (creatine kinase B, energy buffering), MT1X (metallothionein), QPRT (NAD biosynthesis), MACROD1 (ADP-ribosylation repair), ZNF703 (transcription factor). This module reflects a biosynthetic/metabolic reprogramming program in pre-tuft progenitors, combining nucleotide synthesis, methylation, and DNA repair — consistent with active proliferation and early fate commitment.
Genes
Most correlated modules
- Progenitor S-phase · correlation 0.97
- Mitochondrial Biogenesis · correlation 0.97
- Precursor Cell Cycle · correlation 0.97
- G2/M Progenitor Proliferation · correlation 0.97
- Pre-tuft WNT Secretion · correlation 0.96
- Mitochondrial OxPhos Assembly · correlation 0.96
- Secretory Progenitor Commitment · correlation 0.96
- Pre-tuft Biosynthetic · correlation 0.96
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.